IgG2a restriction of murine antibodies elicited by viral infections
نویسندگان
چکیده
The isotypic distribution of IgG antibodies was determined in the serum of mice after infection with a panel of RNA and DNA viruses representative of 11 different genera. The antiviral response induced by all these viruses showed a striking preponderance of the IgG2a subclass whatever the strain of mice tested or the time elapsed after infection. Together with the predominance of IgG1 in antiprotein and of IgG3 in anticarbohydrate response, this IgG2a restriction of antiviral antibodies strongly suggests the existence of highly specific mechanisms for the regulation of individual subclasses in the mouse.
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 165 شماره
صفحات -
تاریخ انتشار 1987